Vitamin B5 deficiency
Vitamin B5 deficiency, also known as hypovitaminosis B5, is extremely rare. Pantothenic acid (vitamin B5) is needed for the formation of coenzyme A, itself essential for the synthesis of acetylcholine and melatonin. Pantothenic acid is also required for normal functioning of the tricarboxylic acid cycle, and therefore normal energy production.
Pantothenic acid is found in virtually all foods and therefore true deficiency is only seen in extreme malnutrition states.
Most of the symptoms associated with pantothenic acid are related to dysfunctional energy generation; these include lethargy, lassitude, nausea, abdominal pains, and irritability. Lack of acetylcholine production may lead initially to paraesthesia or muscle cramps, and over time to chronic tetany.