Thyroseq

Last revised by Dr Henry Knipe on 20 May 2020

Thyroseq® is an expanded gene classifier test designed for further evaluation of indeterminate thyroid nodules on fine needle aspiration (FNA). In particular, it is designed to further evaluate nodules that show atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology. It can also be used to risk-stratify nodules that show follicular neoplasm cytology 2.

The test is a multigene next-generation assay that evaluates for multiple mutations in thyroid cancer. Early results suggest that it offers increased sensitivity and specificity over standard gene expression classifier/AFIRMA testing for detection of cancer in these indeterminate nodules. The most recent iteration of the test is version 3 (as of late 2019). It uses DNA, mRNA, and miRNA markers for evaluation.

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