Substernal goiter

Dr Owen Kang and Dr Bruno Di Muzio et al.

Substernal goiter is a goiter (enlarged thyroid gland) with intrathoracic extension.

It remains unclear which goitres are to be termed substernal, but a recently proposed definition is a goiter that requires mediastinal exploration and dissection for complete removal or an intrathoracic component extending more than 3 cm in the thoracic inlet 1.

Chest x-ray may show a superior mediastinal radiopacity causing the deviation of trachea to opposite site. The superior margin of the radio-opacity/mass is untraceable (cervicothoracic sign).

According to one study the most important CT features in determining the necessity of sternotomy for goiter excision are the presence of an ectopic goiter, total thyroid gland volume and goiter extension below the tracheal carina 3.

Most anterior substernal thyroid goitres are accessed via a transcervical approach. For goitres that cannot be removed via neck dissection, such as those with complicated anatomic extensions or posterior mediastinal involvement, the surgeon may need to incorporate a partial upper sternotomy and clavicular head resection or mini-thoracotomy for adequate exposure.

A surgeon with an understanding of the radiologic reporting of a substernal goiter on a dedicated chest CT might perform a sternotomy instead of a simple low-collar incision for resection of a substernal goiter.

A potential pitfall in the assessment of retrosternal extension is the apparent lower position temporarily assumed by the gland when the arms are raised in the case of imaging aimed at the chest. This can be avoided by having the patient's arms by their side when imaging for retrosternal extension 2

Thyroid pathology
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Article information

rID: 18401
System: Head & Neck
Section: Gamuts
Synonyms or Alternate Spellings:
  • Substernal goiter
  • Retrosternal goitre
  • Retrosternal goiter

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Cases and figures

  • Case 1: multinodular goiter - plain film
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  • Case 1: multinodular goiter - CT
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  • Case 2
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  • Case 3
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  • Case 4
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  • Case 4: retrosternal goiter
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  • Case 5
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  • Case 6
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  • Case 7: multinodular goiter with substernal extension
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  • Case 8
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  • Case 9: mediastinal goiter
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  • Case 10: retrosternal extension
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