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Sickle cell disease (cerebral manifestations)

Last revised by Dr Mohamed Saber on 06 Dec 2020

Cerebral manifestations of sickle cell disease contribute significantly to the overall morbidity of the disease. Sickle cell disease is among the most common causes of stroke in the pediatric population.

For a general discussion of sickle cell disease, please refer to sickle cell disease.

Approximately 25% of patients with sickle cell disease have a neurological event in their lifetime, many of these in childhood 1

Ischemic strokes and cognitive impairment are common, but in many instances, infarcts may be asymptomatic 1-2

Cerebral radiological findings in sickle cell disease include 1-3:

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Cases and figures

  • Case 1: Moyamoya syndrome (with background sickle cell disease)
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  • Case 2: Old multi-territory infarcts in the setting of Sickle Cell.
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