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Respiratory chain metabolic toxins

Last revised by Dr Daniel J Bell on 08 Feb 2021

A number of toxins affect the respiratory chain and result in typical changes within the brain.

They typically result in hypoxic injury to the basal ganglia, initially manifesting as high T2 signal changes on MRI with associated restricted diffusion on DWI and ADC. The pattern of involvement differs somewhat depending on the toxin, and as such is discussed separately in each condition.

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Cases and figures

  • Case 1: carbon monoxide poisoning
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  • Case 2: methanol poisoning
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