Metastases to the breast
Citation, DOI and article data
Metastases to the breast from non-mammary primary tumors are uncommon and account for 0.5-2.0% of all breast malignancies.
Metastases do not tend to cause retraction of the skin or nipple. Metastatic lesions are much more likely to be multiple or bilateral than primary cancers.
Breast metastases from extra-mammary malignancies are unusual, and if present, typically indicate widely disseminated disease. They tend to be found in the subcutaneous fat, whereas primary breast cancers develop in glandular tissue.
The most frequent source of a metastatic breast lesion is the contralateral breast 2. The most common extra-mammary cancers that metastasize to the breast are:
- lymphoma/leukemia: most common extramammary source 2
- prostate cancer: considered on the most frequent primary sites in men 4
- lung cancer
- gastric cancer
- ovarian cancer
- renal cell cancer
- malignant mesothelioma 5
- carcinoid tumor 6
- carcinoma of the cervix 7
- rectal cancer 8
- papillary thyroid carcinoma 9
Like other metastasis, metastases to the breast tend to be rounded and well defined. As opposed to breast cancer, calcification is unusual.
On mammography, metastatic lesions may manifest as single or multiple masses or as diffuse skin thickening. Metastases usually appear as round masses with circumscribed or ill-defined borders. They typically lack spiculation. Microcalcifications are rare can occur with some primary type (e.g, psammoma bodies in ovarian cancer).
On ultrasound, metastatic masses tend to have circumscribed margins with low-level internal echoes and, occasionally, posterior acoustic enhancement. Color Doppler interrogation most often shows increased vascularity.
History and etymology
The first case of a metastatic lesion to the breast is thought to have been reported by Trevithick in 1903 4.
On mammography several other primary breast lesions may easily mimic that of a typical well-defined metastasis which may be benign or malignant:
Rarely, metastasis to the breast may be spiculated and mimic an invasive ductal carcinoma.
- 1. Feder JM, De paredes ES, Hogge JP et-al. Unusual breast lesions: radiologic-pathologic correlation. Radiographics. 1999;19 Spec No : S11-26. - Pubmed citation
- 2. Conant EF, Brennecke CM. Breast imaging, case review. Mosby Inc. (2006) ISBN:0323017460. Read it at Google Books - Find it at Amazon
- 3. Eurorad teaching files : Case 1652
- 4. Eurorad teaching files : Case 7171
- 5.Vergier B, Trojani M, de Mascarel I, et al. Metastases to the breast: differential diagnosis from primary breast carcinoma. (1991) Journal of surgical oncology. 48 (2): 112-6. Pubmed
- 6. C Gupta, A K Malani, S Rangineni. Breast metastasis of ilial carcinoid tumor: Case report and literature review. (2006) World Journal of Surgical Oncology. 4 (1): 15. doi:10.1186/1477-7819-4-15 - Pubmed
- 7. P Yadav, NML Manjunath, SVS Deo, et al. Role of surgery in breast metastasis from carcinoma of the cervix. (2011) Indian Journal of Palliative Care. 17 (1): 74. doi:10.4103/0973-1075.78454 - Pubmed
- 8. Li HC, Patel P, Kapur P, Huerta S. Metastatic rectal cancer to the breast. (2009) Rare tumors. 1 (1): e22. doi:10.4081/rt.2009.e22 - Pubmed
- 9. Kevin C. Brown, Ryan B. et al. Breast Metastasis from Differentiated Thyroid Carcinoma Primary: A Case Report and Review of Literature. (2015) American Journal of Cancer Case Reports. 3 (3): 165-170.