Intraductal papilloma of breast
Citation, DOI and article data
Intraductal papillomas are the most common masses within the milk ducts of the breast. They are benign tumors but may contain areas of atypia or carcinoma. The most common symptom is nipple discharge.
- almost exclusively in women
- extremely rare in males 9
- classically most common during 40-50 years of age (average 48 years old)
- increasing use of breast ultrasound has resulted in more frequent detection of papillary lesions in younger, asymptomatic women
- often asymptomatic (incidental imaging finding)
- nipple discharge: especially if unilateral, spontaneous, persistent
- bloody or clear (serosanguineous) nipple discharge, often less than six months duration
- more common in central versus peripheral papillomas 10
- bloody nipple discharge is thought to be due to twisting of the papilloma on its fibrovascular pedicle, leading to necrosis, ischemia, and intraductal bleeding
- bloody nipple discharge may have higher association with atypical or malignant lesions 11
Papillomas are proliferative tumors originating from the walls of milk ducts, typically growing within the duct and tending to cause local ductal obstruction. They are composed of monotonous epithelial/myoepithelial cells encompassing a papillary fibrovascular core, and characteristically grow to form smooth well-circumscribed nodules.
Papillomas are typically small (<10 mm) lesions but may range from 3 mm to >2 cm 10. They most commonly occur ~3.5 cm from the nipple but may occur anywhere from anterior to posterior depth 10,11.
Increasingly, the central question in the assessment of breast papilloma is whether there is any evidence of cellular atypia. Any finding suggestive of more than merely benign proliferation are generally grounds for surgical excision of the entire lesion. In addition, papillomas have been reported occurring adjacent to other significant lesions such as atypical ductal hyperplasia or DCIS.
Papillomas may be solitary or multiple. Multiple papillomas, especially more than 5 lesions, are considered papillomatosis. There may be a higher rate of associated malignancy with multiple papillomas.
They may be classified by location:
- central: within a major subareolar duct, often solitary
- peripheral: occur within the terminal duct lobular unit, may be multiple
Mammograms are frequently normal (particularly with small intraductal papillomas). When imaging findings are present, they include solitary or multiple dilated ducts, a circumscribed benign-appearing mass (often subareolar in location), or a cluster of calcifications.
Galactography usually reveals a filling defect or other ductal abnormalities, such as ectasia (usually between the nipple and filling defect), obstruction, or irregularity. However, these findings are non-specific.
Galactography may outline the number, location, extent, and distance from the nipple.
Papilloma may be seen as a well-defined solid nodule or intraductal mass which may either fill a duct or be partially outlined by fluid - either within a duct or by forming a cyst. Color Doppler will demonstrate a vascular stalk.
A dilated duct can be frequently visible sonographically.
Most commonly appear as modestly-T2-bright, circumscribed, solid enhancing lesions. Morphological characteristics on MR may be quite variable:
- shape: can be oval/round (~75%) or irregular (~25%) shape 10,11
- margin: smooth or irregular (spiculation suggests malignancy) 10
- consistency: mostly solid (~90%), but can be cystic or complex cystic 11
- T1: isointense to slightly hypointense relative to breast glandular tissue 10
- T2: hyperintense to breast glandular tissue, but less bright than cysts 10
T1 C+ 10
rapid early enhancement
- absolute enhancement rate may be somewhat less than DCIS
- may be a homogeneous or heterogeneous pattern
- may show peripheral ("rim-like") hyperenhancement on delayed images
- dynamic enhancement pattern non-specific; all 3 types of kinetics (persistent, plateau, and washout) have been described 10,11
- rapid early enhancement
- DWI/ADC: restrict diffusion (high DWI, low ADC values) 10
- may be associated with mildly increased (less than liver) FDG-avidity
- at least one report of markedly increased (SUV 10-12) avidity in a papilloma with strong expression of GLUT-1transporter 8
Treatment and prognosis
Most centers treat solitary intraductal papillomas with surgical excision, even after benign biopsy, to exclude components of atypia or neoplasia. However, there is some controversy surrounding this, with some groups suggesting that clinical follow-up is sufficient if there is no atypia (including ADH) on core biopsy 7.
Given the increased risk of malignancy over a woman's lifetime when this lesion is diagnosed, compliance with screening recommendations for such patients is strongly advisable.
According to a consensus committee of the College of American Pathologists, women with this lesion have a relative risk of 1.5-2 times for developing invasive breast carcinoma in their lifetime.
The differential includes other solid tumors that can occur in the large ducts, specifically:
- ductal carcinoma in situ
- invasive ductal carcinoma with an in situ component
- papillary carcinoma of the breast can mimic an intraductal papilloma (particularly on ultrasound)
For ultrasound appearances also consider:
- 1. Pisano ED, Braeuning MP, Burke E. Diagnosis please. Case 8: solitary intraductal papilloma. Radiology. 1999;210 (3): 795-8. Radiology (full text) - Pubmed citation
- 2. Ganesan S, Karthik G, Joshi M et-al. Ultrasound spectrum in intraductal papillary neoplasms of breast. Br J Radiol. 2006;79 (946): 843-9. doi:10.1259/bjr/69395941 - Pubmed citation
- 3. Conant EF, Brennecke CM. Breast imaging, case review. Mosby Inc. (2006) ISBN:0323017460. Read it at Google Books - Find it at Amazon
- 4. Paredes ES. Atlas of mammography. Lippincott Williams & Wilkins. (2007) ISBN:0781764335. Read it at Google Books - Find it at Amazon
- 5. Woods ER, Helvie MA, Ikeda DM et-al. Solitary breast papilloma: comparison of mammographic, galactographic, and pathologic findings. AJR Am J Roentgenol. 1992;159 (3): 487-91. AJR Am J Roentgenol (abstract) - Pubmed citation
- 6. Eiada R, Chong J, Kulkarni S et-al. Papillary lesions of the breast: MRI, ultrasound, and mammographic appearances. AJR Am J Roentgenol. 2012;198 (2): 264-71. doi:10.2214/AJR.11.7922 - Pubmed citation
- 7. Agoff SN, Lawton TJ. Papillary lesions of the breast with and without atypical ductal hyperplasia: can we accurately predict benign behavior from core needle biopsy?. Am. J. Clin. Pathol. 2004;122 (3): 440-3. doi:10.1309/NAPJ-MB0G-XKJC-6PTH - Pubmed citation
- 8. Jinguji M, Kajiya Y, Nakajo M, Higashi M, Yoshiura T. A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT. (2015) Clinical nuclear medicine. 40 (11): 905-7. doi:10.1097/RLU.0000000000000873 - Pubmed
- 9. de Vries FE, Walter AW, Vrouenraets BC. Intraductal papilloma of the male breast. (2016) Journal of surgical case reports. doi:10.1093/jscr/rjw014 - Pubmed
- 10. Ying Zhu, Shuping Zhang, Peifang Liu, Hong Lu, Yilin Xu, Wei T. Yang. Solitary Intraductal Papillomas of the Breast: MRI Features and Differentiation From Small Invasive Ductal Carcinomas. (2012) American Journal of Roentgenology. 199 (4): 936-42. doi:10.2214/AJR.12.8507 - Pubmed
- 11. Li-Jun Wang, Ping Wu, Xiao-Xiao Li, Ran Luo, Deng-Bin Wang, Wen-Bin Guan. Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients. (2018) World Journal of Surgical Oncology. 16 (1): 234. doi:10.1186/s12957-018-1537-9 - Pubmed