Intracystic papillary carcinoma (breast)
Citation, DOI and article data
As with papillary carcinomas in general, it tends to occur in postmenopausal women.
Pathologically, intracystic papillary carcinomas may show four cellular patterns:
- compact columnar epithelial
- stratified spindle cell
- transitional cell form resembling urothelium
The combination of two or more of these patterns may also be seen.
Some report value in measuring CEA levels in the aspirated cyst fluid 3.
On mammography, an intracystic papillary carcinoma is often seen as a round or oval circumscribed mass, most frequently in the retroareolar region.
The usual ultrasound appearance is a cystic mass, with or without septations, with solid papillary masses projecting into the cyst lumen.
Treatment and prognosis
A segmental mastectomy is usually performed, and axillary lymph node sampling (axillary lymph node dissection or sentinel lymph node mapping) is suggested in patients in whom invasion is likely.
Intracystic papillary carcinoma has a slow growth rate and an excellent prognosis with 10-year survival rates approaching 100% 1,2.
- 1. Wagner AE, Middleton LP, Whitman GJ. Intracystic papillary carcinoma of the breast with invasion. AJR Am J Roentgenol. 2004;183 (5): 1516. AJR Am J Roentgenol (full text) - Pubmed citation
- 2. Dogan BE, Whitman GJ, Middleton LP et-al. Intracystic papillary carcinoma of the breast. AJR Am J Roentgenol. 2003;181 (1): 186. AJR Am J Roentgenol (full text) - Pubmed citation
- 3. Matsuo S, Eto T, Soejima H et-al. A case of intracystic carcinoma of the breast: the importance of measuring carcinoembryonic antigen in aspirated cystic fluid. Breast Cancer Res. Treat. 1993;28 (1): 41-4. - Pubmed citation
- 4. Knelson MH, El yousef SJ, Goldberg RE et-al. Intracystic papillary carcinoma of the breast: mammographic, sonographic, and MR appearance with pathologic correlation. J Comput Assist Tomogr. 11 (6): 1074-6. - Pubmed citation
- 5. Ienzi R, Cirino A, Galia M et-al. [Intracystic papillary carcinoma of the breast: mammographic, pneumocystographic, sonographic, power-Doppler and MR appearance: a case report]. Radiol Med. 102 (5-6): 403-5. - Pubmed citation
- 6. Kyriazis AP, Kyriazis AA. Intracystic papillary carcinoma of the female breast with secretory activity: the significance of aspiration cytology as diagnostic procedure. Diagn. Cytopathol. 1995;13 (4): 322-4. - Pubmed citation