HIV associated neurocognitive disorders

HIV associated neurocognitive disorders (HAND), which is a new term emerged from an international conference in 2006 1, correspond to a group of clinical syndromes related to the HIV infection in the cells of the nervous system expressing different degrees of impairment of cognition and associated functioning. They are part of neuroAIDS.  

Three different clinical conditions were defined 1-3:

  • asymptomatic neurocognitive impairment (ANI): characterized by impairment in cognitive function clinically diagnosed, however the everyday functioning is not affected.
  • mild neurocognitive disorder (MND): characterized by impairment in cognitive function clinically diagnosed and mild interference in everyday functioning.
  • HIV-associated dementia (HAD): characterized by marked impairment in cognitive function which significantly limits abilities to function in daily work, home and social activities. It was previously referred as AIDS dementia complex and is the only condition which express clear recognisable features of HIV encephalopathy on MRI. 
Infections of the central nervous system
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Article information

rID: 38006
Synonyms or Alternate Spellings:
  • HAND

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