Hepatic amyloidosis

Hepatic amyloidosis refers to the extracellular deposition of amyloid in the parenchyma sinusoids or vessel walls. Liver involvement in amyloidosis is uncommon.  

It can be primary or secondary and it typically occurs as diffuse infiltration 2.

There is amyloid deposition in liver parenchyma which occurs along the sinusoids within the space of Disse, or in blood vessel walls. Hepatocytes can be markedly compressed by extensive accumulation of amyloid and they may atrophy or nearly disappear.

In advanced cases with massive infiltration, the liver is enlarged with a rubbery elastic consistency, and it may show 'lardaceous liver' appearance.

Hepatomegaly and heterogeneous appearances of the liver parenchyma are the most common, though nonspecific, imaging features 7

Non-specific and may show heterogeneous hepatic echotexture 3 or diffuse or focal areas of low attenuation 7. Prominent calcifications can be rarely seen. 

There can be hepatomegaly with decreased hepatic attenuation 2. Some calcification may be present.

  • T1: has increased signal through the liver 1,3
  • T2: little change 3

For CT appearances of decreased hepatic attenuation: see causes of decreased hepatic attenuation.

Hepatobiliary pathology
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Article information

rID: 23451
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Liver amyloidosis
  • Amyoidosis of the liver
  • Amyoidosis involving the liver

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