Endomyocardial fibrosis

Endomyocardial fibrosis (EMF) is an idiopathic disorder characterized by the development of restrictive cardiomyopathy.

It usually occurs in tropical and subtropical regions of the world.There may be a greater predilection in children and adolescents. 

It can occur as part of idiopathic hypereosinophilic syndrome 2, resulting in so-called Loeffler endocarditis.

The condition usually carries high morbidity and mortality with mean survival after diagnosis around two years. Death often results from chronic heart failure, arrhythmia and thromboembolism 5. Surgery may correct some structural and functional abnormalities but with uncertain, long-term outcomes.

It is thought to have been first described by W R Hardy and R E Anderson in 1968 4.



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Article information

rID: 56852
System: Cardiac
Synonyms or Alternate Spellings:
  • Endomyocardial fibrosis (EMF)
  • Tropical Endomyocardial Fibrosis

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