Comedo type ductal carcinoma in situ
Citation, DOI and article data
A comedo-type ductal carcinoma in situ, also known as comedocarcinoma in situ is the high grade subtype of ductal carcinoma in situ (DCIS). It completely fills and dilates the ducts and lobules in TDLU with plugs of high grade tumor cells with central necrosis "comedonecrosis".
It is the most aggressive of intraductal carcinomas. In 30% of cases it can be multicentric and / or multifocal.
Casting-type microcalcifications are the most frequent mammographic finding (78% of cases) in comedotype DCIS.
Histologically DCIS-comedo is diagnosed when at least one duct in the breast is filled and expanded by large, markedly atypical cells.
It has the risk of occult infiltration. A comedo that extends for more than 2.5 cm has the combination of invasive component in 45% of cases.
Infiltrating ductal carcinoma (infiltrative ductal carcinoma with central necrosis) may so closely mimic the pattern of DCIS with central comedonecrosis that on initial morphological analysis these foci of tumors are often labeled as DCIS (high grade, comedo type).
- 1. Tavassoli FA. Pathology of the breast. McGraw-Hill Professional. (1999) ISBN:0838577040. Read it at Google Books - Find it at Amazon
- 2. Rovere GQ, Warren R, Benson JR. Early breast cancer, from screening to multidisciplinary management. Informa HealthCare. (2006) ISBN:1841843849. Read it at Google Books - Find it at Amazon
- 4. Grio R, Macchioni S, Zaccheo F et-al. [Infiltrating comedocarcinoma of the breast]. Minerva Ginecol. 1985;37 (10): 565-9. - Pubmed citation
- 5. Bongiorni G, Marchisio V, Bragaja S. [Comedocarcinoma: a tumor histotype to be reevaluated]. Radiol Med. 1990;79 (6): 590-2. - Pubmed citation
- 6. Phillips LS, Millikan RC, Schroeder JC et-al. Reproductive and hormonal risk factors for ductal carcinoma in situ of the breast. Cancer Epidemiol. Biomarkers Prev. 2009;18 (5): 1507-14. doi:10.1158/1055-9965.EPI-08-0967 - Pubmed citation
- 6. Leonard GD, Swain SM. Ductal carcinoma in situ, complexities and challenges. J. Natl. Cancer Inst. 2004;96 (12): 906-20. J. Natl. Cancer Inst. (link) - Pubmed citation
- 8. Pervez S, Khan H. Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case series. J Med Case Reports. 2007;1 : 83. doi:10.1186/1752-1947-1-83 - Free text at pubmed - Pubmed citation